EGF and colorectal carcinoma: Since several cytokines or growth factors, well recognized as prognostic factors for CRC, including platelet-derived growth factor (PDGF) [8], tumor necrosis factor-α (TNF-α) [9], interleukins (ILs) [10], epidermal growth factor (EGF) [11], vascular endothelial growth factor (VEGF) [12] basic fibroblast growth factor (bFGF) [13,14] and the TGFβ [15] interact with TATA box and AP-1 elements, we surmise that they can participate in deregulation of MMP expression in CRC.