In particular, the expression levels of MMP1, MMP3, MMP7, MMP9, MMP10, MMP11, MMP12, MMP13, and MMP14 were significantly upregulated in CRC tumor tissues compared to normal tissues, while MMP15, MMP17, MMP25, MMP27, and MMP28 were significantly downregulated. The gene discussed is MMP12; the disease is neoplasm.