MMP13 and neoplasm: Interestingly, 14 of 24 MMP members were soundly deregulated (Table 2); among these, MMP1, MMP3, MMP7, MMP9, MMP10, MMP11, MMP12, MMP13, and MMP14 were significantly upregulated in tumor tissues, while MMP15, MMP17, MMP25, MMP27, and MMP28 were significantly downregulated in CRC compared with normal tissues.