CNR2 and osteoporosis: In order to assess the susceptibility to osteoporosis in patients carrying CB2 SNPs, Yamada et al. designed a prospective study in which they evaluated 1110 women and 1128 Japanese men aged 40–79 years for the association between BMD at different sites and the presence of SNP rs2501431, which was the most promising in the Karsak cohort [108].