Within the top 50 DEGs, various genes previously connected with drug metabolism/resistance (e.g., ALDH2), cell cycle (e.g., CDK2AP1), MTORC signaling (e.g., LAMTOR5), and Wnt/β-catenin signaling (e.g., SP5), as well as the CRC biomarker CEACAM6, were influenced by reduced p130Cas levels (Figure 5B). The gene discussed is SP5; the disease is colorectal carcinoma.