Other studies showed the involvement of p130Cas in α1-integrin/c-Src-mediated invasion of CRC cells [24], in c-Src regulated PI3K/AKT-driven colon tumorigenesis [25,26], and cysteine-rich protein 2 (CSRP2) controlled suppression of CRC progression [27]. Here, PIK3CA is linked to colorectal carcinoma.