These and other studies showed that Wnt/β-catenin, KRAS/mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase/AKT serine-threonine protein kinase (PI3K/AKT) signaling pathways are commonly deregulated in CRC [10,11]. This evidence concerns the gene KRAS and colorectal carcinoma.