HLA-C and neoplasm: Transfection with DNA and RNA has been tested and has a lot of advantages: (a) generation of large amount of immunogenic DNA/RNA to be used in clinical application, even when tumor tissue is limited and/or difficult to be obtained; (b) increased efficiency of the immune response induction; (c) nucleic acid-based constructs involve synthesis of antigens that can be expressed, processed and presented in a complex with MHC molecules for a long time and efficiently, inducing T cells immune response [38,42,45].