In the murine model of glioma GL261, Newcomb et al. observed that whole-body radiotherapy (WBRT) was able to induce upregulation of β2-microglobulin light chain subunits of the MHCI complex on glioma cells, with a concomitant increase of CTLs and infiltration of helper T cells. This evidence concerns the gene HLA-G and central nervous system cancer.