As mentioned before, the stimulation of HeLa cells with 0.3 mM CoCl2 stabilizes endogenous HIF-1α protein, and this raises the level of the target genes to adapt the tumor cells to the hypoxic environment, whereas CAY10585 is a well-known inhibitor of the activity of HIF-1α that decreases the level of the target genes. Here, HIF1A is linked to neoplasm.