Several studies have now consolidated the pivotal role of Neutrophil Gelatinase-Associated Lipocalin (NGAL), also known as Lipocalin-2, in the crosstalk between cancer cells and the different cell populations of tumor microenvironment, given its multifaceted functions as inflammatory and innate immunity protein [15,16,17,18,19,20,21]. This evidence concerns the gene LCN2 and cancer.