LCN2 and neoplasm: Since siderophores represent the major source of iron load for NGAL and, more importantly, since Bao and co-workers brilliantly demonstrated in 2010 that the substitution of two key aminoacids (Lys125 and Lys134) in the NGAL siderophores binding region completely blocked NGAL iron load [104], it is conceivable that interfering with siderophores binding rather than with iron chelation could be a winning strategy to target NGAL in tumor microenvironment.