FSHR and hypogonadotropic hypogonadism: Mutation-provoked misfolding of GPCRs involved in the regulation of reproductive function may also occur [10,42], and lead to distinct abnormalities, including hypogonadotropic hypogonadism [due to mutations in the human gonadotropin-releasing hormone receptor [43], neurokinin-3 receptor (NK3R), prokineticin receptor-2 (PROKR2), or kisspeptin receptor-1 (KISS1R) [44,45,46], male pseudohermaphroditism (due to mutations in the luteinizing hormone/chorionic gonadotropin receptor; LHCGR), and ovarian failure (mutations in the follicle-stimulating hormone receptor; FSHR) [42].