The signatures of WNT/TGF-β, TGF-β 1, and extracellular matrix cytokines (C-ECM) were more enriched in the immune-suppressed (stromal-activated) subtype than in the non-immune class (p < 0.05): these cases showed increased expression of IL-11, TGFB1, and TGFB2, and high expression of tumor-infiltrating regulatory T cell (Treg) signatures (p < 0.05). Here, TGFB1 is linked to neoplasm.