In a PC series, CTHRC1 overexpression was associated with worse disease-free-survival, upregulation of PD-1 and PD-L1, increased inflammatory infiltrates (B cells, CD4+ T cells, macrophages, neutrophils and dendritic cells) and increased expression of matrix metalloproteinase-9, mucin 1 and SLCO2B1 (solute carrier organic anion transporter family member 2B1) genes [120]. This evidence concerns the gene CD4 and pachyonychia congenita.