Colony-stimulating factor (CSF)-1 controls the differentiation, proliferation, and survival of macrophages by binding to CSF1 receptor, expressed on macrophages: increased Δ133TP53β mRNA in PC was characterized by an immunosuppressive phenotype and increased frequency of PD-1, PD-L1, and CSF1 receptor-positive cells [40]. Here, CD274 is linked to pachyonychia congenita.