In vitro experiments on PC cells suggested that adipokines/proinflammatory cytokines such as leptin (a protein hormone expressed by adipocytes, with a role in regulating body weight, metabolism, and reproductive function) and IL-6 can induce resistance of CRPCs to NK cell action via the JAK/STAT3 pathway, thus regulating the PD- L1/NKG2D ligand levels. This evidence concerns the gene LEP and pachyonychia congenita.