Analysis of the data available on cBioPortal online database (https://www.cbioportal.org/; accessed on 1 October 2021) revealed that 102/8590 (1.2%) of PC cases included in this dataset harbored genetic alterations of CD274 gene, including mutations (6%), amplifications (11%) and deep deletions (83%) (Figure 3). The gene discussed is CD274; the disease is pachyonychia congenita.