PPARG and brain ischemia: It has been demonstrated that in rat model of cerebral ischemia, pioglitazone was able to activate innate stem cells in the subventricular zone (SVZ) and recruitment of bone marrow (GFP+BM) stem cells with an increase in PPAR-γ and then increased the expression of Akt, Map2, and Vegf in the cortical peri-infarct area, leading to neurogenesis.