In the study with the same experimental design, PPT, but not diaryl-propio-nitrile (DPN), resulted in attenuated cofilin phosphorylation, suggesting that ERα, but not ERβ, mediated the inhibitory effect of estrogen on cofilin phosphorylation and thus on cardiac fibrosis after MI [78]. This evidence concerns the gene ESR1 and myocardial infarction.