In addition, miR-195 and miR-16 overexpression increases the radiosensitivity of cancer cells; in vitro and in vivo restoration of their expression enhanced radiotherapy via T cell activation in the tumor microenvironment by blocking the PD-L1 immune checkpoint in PC cells, suggesting a synergistic effect of immunotherapy and radiotherapy [73]. This evidence concerns the gene CD274 and pachyonychia congenita.