KCNQ1OT1 and pachyonychia congenita: In PC cell lines, KCNQ1OT1 sponged miR-15a, suppressing the miR-15a-mediated inhibition of PD-L1, thus leading to PD-L1 upregulation, the inhibition of CD8+ T-cells cytotoxicity, and the promotion of tumor evasion [26].