CD274 and pachyonychia congenita: In PC models [158], EZH2 inhibition activates a double-stranded RNA–STING (stimulator of interferon genes)–ISGs (interferon-stimulated genes) stress response in tumor cells, upregulating genes involved in antigen presentation, Th1 chemokine signaling, and interferon response, including PD-L1 (dependent on STING activation) [158].