The histone methylation regulator WDR5 is an important component of the SET1/MLL histone-methyltransferase complex and a critical co-activator of oncogenic pathways via the H3K4me3/c-MYC-dependent transcriptional activation of target genes, favoring tumor proliferation, metastases, chemoresistance, and AR-mediated castration-resistance [14]. The gene discussed is PRDM9; the disease is neoplasm.