In PC cell lines, the IFN-γ-induced PD-L1 mRNA and protein levels were significantly abrogated by WDR5 or MLL1 knockdown (not by c-MYC silencing), as well as by OICR-9429 (a highly selected and potent antagonist of WDR5 interactions with MLL1, c-MYC, and other partners) [14]. This evidence concerns the gene MYC and pachyonychia congenita.