When cells were treated with memantine or bCDsuMema nanoparticles, the oxidative-mediated expression of the NMDAR1 protein in cells was significantly decreased, indicating that bCDsuMema nanoparticles have the capacity to suppress NMDAR1 expression in brain cells, which has relevance to applications in Alzheimer’s disease. Here, GRIN1 is linked to early-onset autosomal dominant Alzheimer disease.