In allograft PC-models, 3 x 5 Gy hypofractionated RT can result in tumor growth delay, increased tumor-associated macrophages and dendritic cells, and upregulation of PD-1/PD-L1, as well as of CD8+ T-cell, dendritic cell, and Tregs genes [106,107,121]. This evidence concerns the gene CD274 and neoplasm.