In in vitro PC-models, Sigma1 inhibitors—such as 1-(4-Iodophenyl)-3-(2-adamantyl) guanidine (IPAG)—may regulate the transport and stability of PD-L1 in cancer cells, suppressing the IFN-γ-induced PD-L1 surface expression and causing selective autophagic PD-L1 degradation on the endoplasmic reticulum [138]. Here, CD274 is linked to cancer.