PDCD1 and pachyonychia congenita: However, an experimental study [145] found that anti-human-PSMA CAR-T cell monotherapy of Myc-CaP (murine PC cell lines) PSMA+ tumors was ineffective, while the combination of anti-human-PSMA CAR-T cells and anti-human-PD1 murine antibody provided a short-duration, sub-optimal response to therapy.