TNF and pachyonychia congenita: miR-195 and miR-16 enhanced the RT-efficacy in PC cell lines, by regulating immunocyte production, activating cytotoxic T cells and reducing regulatory cytokine secretions (such as IFN-γ, TNF-α, and IL-2) in the tumor microenvironment; this synergy was accompanied by the proliferation of functional cytotoxic CD8+ T cells and inhibition of MDSCs and Tregs.