Among the highly expressed genes responding to acute lactate exposure (Lat110 population) we found several heat shock proteins: Hsp26 (YBR072W; SSD), Hsp30 (YCR021C), Hsp42 (YDR171W), Hsp78 (YDR258C), Hsp82 (YPL240C; WGD) Sse2 (YBR169C), Ssa4 (YER135C), Hsp104 (YLL026W; SSD), Ssc1 (YJR045C, HSP70 family ATPase, WGD); chaperone Apj1 (YNL077W; SSD); co-chaperones Mdj1 (YFL088W) and Sis1 (YNL007C), all involved in protein folding/refolding under heat-shock and stressing conditions (including lactic acidosis of the environment), some of them with implications on DNA replication stress. Here, CLPB is linked to lactic acidosis.