In addition to the important role of STAT3 activation in mediating radioresistance of HNSCC, another study found that in radioresistant HNSCC cells, STAT1 was the most highly expressed STAT protein and transduction of radiosensitive HNSCC cells with STAT1 induced radioresistance [66]. The gene discussed is STAT1; the disease is head and neck squamous cell carcinoma.