Therefore, the final consequences of the IFN signaling may well depend on the duration (acute vs. chronic), signaling strength (the amount cytokine produced and/or the receptor expression level), the specific signaling molecules involved (JAK1-STAT1 vs. JAK2-STAT3/5), as well as tumor types and/or stages (early vs. late). The gene discussed is JAK2; the disease is neoplasm.