An early study showed that a single dose of RT (15 Gy) in B16-OVA melanoma significantly upregulated vascular cell adhesion molecule 1 (VCAM-1), monokine induced by gamma interferon (MIG, better known as CXCL9), CXCL10, and MHC-I; all are important immunostimulatory molecules in driving immune cell extravasation and infiltration. The gene discussed is IFNG; the disease is melanoma.