Furthermore, in vitro treatment of gastric cancer cells with IFN-γ led to PD-L1 expression through JAK-STAT but not MAPK and PI3K pathway, couple with impaired cytotoxicity of tumor antigen-specific CD8+ T cells and EMT phenotype of tumor cells, which could be overcome by anti-PD-1 [109]. The gene discussed is CD8A; the disease is neoplasm.