To this end, a recent study reported that single high-dose RT (20 or 30 Gy) actually induced expression of the three prime repair exonuclease 1 (Trex1) that degraded cytosolic dsDNAs and attenuated the cGAS-STING pathway in tumor cells, thereby lowering production of IFN-β by tumor cells. The gene discussed is CGAS; the disease is neoplasm.