Therefore, to assess the effect of ELF3 on lung cancer cell survival, we knocked down the expression of ELF3 by transfecting ELF3 siRNA into A549 (with K-Ras mutation) and H1975 (with EGFR L858R/T790M double mutation) lung cancer cells for 72 h. The gene discussed is KRAS; the disease is lung carcinoma.