TCF7L2 and malignant colon neoplasm: Similarly, YB-1 and TCF7L2 have been reported in association with colon cancer cells, wherein YB-1 is involved in cell proliferation, migration, apoptosis, and EGFR expression in colorectal cancer [24], and TCF7L2 is involved in the Wnt/β-catenin signaling pathway; polymorphism in that gene has been associated with increased risk of colon cancer [25].