TRPA1 and migraine disorder: Given that CSD is known to activate and sensitize the TVS [51,52] and taken together with our above findings, it is possible that the reduced cortical susceptibility to CSD under inhibition of TRPA1/SFKs signaling may subsequently have a negative impact on the hypersensitivity of the TVS induced by CSD or other migraine triggers, but this requires future clarification.