BCL2 and cancer: All the tested compounds (4, 5a–l) were found to inhibit the growth of the Bcl-2-expressing human cancer cell lines (MDA-MB-231, HeLa and KG1a) with low micromolar IC50 values, except 5c, which was inactive against the KG1A (Acute Myeloid Leukemia) cell line (Table 1).