The density of CB1 receptors was also increased in 3xTg-AD mice at the brain areas with the highest CB1 densities, such as the cerebellar gray matter (3xTg-AD 414.3 ± 17.3 fmol/mg t.e. vs. WT 299.5 ± 16.8 fmol/mg t.e.; p < 0.01) and the substantia nigra (3xTg-AD 375.9 ± 25.2 fmol/mg t.e. vs. WT 263.8 ± 21.9 fmol/mg t.e.; p < 0.01) (Supplementary Material Table S1, Figure S1). The gene discussed is CNR1; the disease is Alzheimer disease.