MAPT and Alzheimer disease: The progressive and irreversible deterioration of cognitive functions present in Alzheimer’s disease (AD) include a chronic neurodegeneration characterized by pathological hallmarks including the loss of synapses, the intracellular neurofibrillary tangles (NFT) (mostly composed by hyperphosphorylated tau protein) [1], and extracellular neuritic plaques (enriched in Aβ) [2,3].