The results are discussed in the framework of the lipid composition of the brains in these mice obtained by the MALDI-MSI technique for the in situ analysis, contributing to understand the lipid changes already observed in AD patients and connect these results with the possible adaptations in the activity induced by three different neurolipid-mediated signaling systems: eCB, LPA, and S1P. This evidence concerns the gene MBTPS1 and Alzheimer disease.