It has been described some degree of myelination disruption in 6-month-old 3xTg-AD mice (early pathological stage) in subregions of hippocampus and entorhinal cortex, together with hyperphosphorylated tau, and a decline of myelin basic protein and 2’,3’-Cyclic-nucleotide 3’-phosphodiesterase expression levels, which are myelin and oligodendrocytes major proteins [78]. This evidence concerns the gene CNP and Alzheimer disease.