Guggulsterone extracted from Commiphora mukul reportedly induces apoptosis via the upregulation of GRP78, PERK, p-Jun N-terminal kinase (p-JNK), CHOP, and DR5 in Hep3B cells; further, CHOP knockdown inhibited the anti-cancer effect of guggulsterone [32]. Here, DDIT3 is linked to cancer.