Nitidine chloride, a natural compound extracted from the root of Zanthoxylum nitidum, exerts powerful anti-glioma effect in vitro and in vivo via the inhibition of EMT markers, including N-cadherin, vimentin, and Slug, and the phosphorylation of the ER stress marker eIF2α [62]. This evidence concerns the gene SNAI2 and central nervous system cancer.