Furthermore, JI017 mediates ER stress and cell death by activating the PERK–eIF2α–ATF4–CHOP signaling pathway in ovarian cancer cells, and combined treatment of radiation and JI017 overcomes radioresistance by inhibiting EMT phenomena, such as the reduction of E-cadherin and the increase of N-cadherin, vimentin, Snail, and Slug in radioresistant ovarian cancer cells. Here, EIF2AK3 is linked to ovarian cancer.