Dehydrocostuslactone, a sesquiterpene lactone extracted from Saussurea lappa and Aucklandia lappa, activates PERK–CHOP and IRE1α–JNK–CHOP signaling pathways by releasing intracellular ROS and intracellular Ca2+ in NSCLC, A549, and NCI-H460 cells, leading to apoptosis [31]. Here, ERN1 is linked to non-small cell lung carcinoma.