SHISAL2B and metastatic malignant neoplasm in the lymph nodes: Analyses of only GEP-NEN revealed significantly higher FAM159B IRS values in patients free of lymph node metastases vs. those with metastases (mean ± SEM: 5.979 ± 0.624 vs. 4.431 ± 0.296, respectively; Mann-Whitney U test: p = 0.041).