Low expression of FAM159B (3 ≤ IRS ≤ 5) occurred in papillary thyroid carcinomas, squamous cell carcinomas of the lung, gastric adenocarcinomas, colon carcinomas, pancreatic adenocarcinomas, breast carcinomas, cervical cancer and melanomas. The gene discussed is SHISAL2B; the disease is differentiated thyroid carcinoma.