For example, mutations in the DNA glycosylase MUTYH and nth like DNA glycosylase 1 (NTHL1), which remove 8-oxoguanine and thymine glycol paired with adenine, respectively, result in colorectal cancer predisposition [91,92,93], while chronic 8-oxoguanine accumulation at telomeres in OGG1 knockout cells triggers replication stress and significantly increases telomere loss, resulting in chromatin instability [94]. This evidence concerns the gene NTHL1 and colorectal cancer.