Knock out mice were also produced by the Knock-Out Mouse Program (KOMP) and the zinc finger nuclease (ZFN)-mediated genome editing and they displayed splenomegaly and lymphadenopathy, with engorged macrophage-like cell accumulation [133,135] and age-related neuroinflammation, like that observed in C9orf72-related ALS patients [133]. This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.