With regards to rats, it has been reported that ablation of the C9orf72 gene, using the CRISPR/cas9 technique, produced only some alterations to cervical lymph nodes and spleen, but no MN loss, thus supporting the notion that C9orf72 LoF alone is not responsible for ALS-like degeneration [142]. The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.