In other cases, mutant phenotypes cannot be clearly distinguished from those carrying WT TDP-43, since the latter shows similar characteristics to the mutant forms; in fact, also the overexpression of the human WT TDP-43 may cause aberrant eye morphology, eclosion defect, climbing and crawling defect, learning deficiency, vesicle transport dysfunction, increased or no change of dendritic branching at NMJs, and TBPH aggregates [233,235,237,239,247]. The gene discussed is TARDBP; the disease is hyperinsulinemic hypoglycemia, familial, 4.