Besides MNs loss, canine models affected by CDM share some other pathological features with SOD1-ALS rodent models and patients, such as oligodendrocyte injury, leading to demyelination [358], increase of arginase 1-expressing microglia in the proximity of MNs [359], and upregulation of CB2 receptors in reactive astrocytes [360]. Here, SOD1 is linked to amyotrophic lateral sclerosis.