Third, we have indirect evidence suggesting an association of angptl2-related senescence with severe obesity: in patients undergoing bariatric surgery, the relatively low reduction in angptl2 circulating levels after the surgery (0% at 6 months, 18% at 1 year) did not reflect the drastic weight reduction (27% at 6 months, 37% at 1 year) [179]. This evidence concerns the gene ANGPTL2 and obesity disorder.