In brain diseases, the role of angptl2 is less studied [43,194], although angptl2 binds to human leukocyte immunoglobulin-like receptors LILRB2 [30], which are also the receptors for β-amyloid, the hallmark of Alzheimer’s disease [195]. Here, ANGPTL2 is linked to early-onset autosomal dominant Alzheimer disease.