ANGPTL2 and cancer: Finally, angptl2 is associated with many age-related pathologies to which cellular senescence has been shown to contribute, such as rheumatoid arthritis [180], osteoarthritis [181,182,183], gout [184], sarcopenia [95], macular dysfunction and visual impairment [185,186], atherosclerosis [29,53,187], heart diseases [102,188,189], kidney diseases [54,176,190,191], and cancer [192,193].