The images of the cancer cells showed that the HER2-positive cells (SK-BR3, MDA-MB361, and JIMT1) exposed to NIR-PIT with the HER2 Affibody-IR700Dye conjugate or the trastuzumab-IR700Dye conjugate displayed morphological evidence of cellular bursting and bleb formation, whereas the morphology of HER2-negative cancer cells (MCF7) remained unchanged (Supplementary Figure S1). Here, ERBB2 is linked to cancer.