EZH2 and cancer: MiRNAs with a tumor-suppressor role include: miRNA-27b, which inhibits cell proliferation, migration, and invasion in OSCC [14]; miRNA-200 [33], which inhibits cell growth at increased salivary concentrations [13]; miRNA-375, found to act as tumor-suppressor in multiple cancers, including OSCC [15]; and miRNA-26a, which inhibits cell migration and metastasis and lowers the expression of enhancer of zeste homolog 2 (EZH2), reducing cell growth [17].