As shown in Figure 9, the histopathological and immunohistochemical analysis showed that DOTA-NIR790-mediated photothermal therapy can cause necrosis and vacuolation in the internal tissues of the tumor, inhibit the ability of tumor cell replication (decreased expression of PCNA), and the high expression of HSP protein revealed that the tumor tissue received thermal shock by the photothermal therapy. Here, PCNA is linked to neoplasm.