In the previous studies, it was shown that TDP-43 may act as a co-activator of the p65 subunit of NF-κB in the models of ALS [23] and stroke [47], and that it is involved in the proinflammatory genes’ transcription as well as in the inflammation-mediated neurodegeneration [23]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.