TGFB1 and acute myeloid leukemia: On the other hand, exosomes alter the immune activity of NK cells by carrying or releasing cytokines and other substances, including IL-15Rα, HSP 70 [70], TGF-β, MICA008, STAT5, JAK3, cyclind3, perforin, etc. Several studies have shown that TGF-β1 carried by TEXs impaired NK cells cytotoxicity and lowered NKG2D expression in the NK cells of acute myeloid leukemia patients [43].