Although Keller et al. reported no correlation between the risk of AD and rs3761740 alone among APOE4 carriers, the minor A allele of rs3761740 increased the risk by 36% (OR = 6.21; p < 0.001) compared to the group carrying only APOE4 (OR = 4.57; p < 0.001) [81]. The gene discussed is APOE; the disease is Alzheimer disease.