Ganglioside GD3 and both mRNA and protein levels of ST8SIA1 were most suppressed by porcine ST8SIA1 siRNA (siST8SIA1) #4 (si#4) in mp AD-MSCs (Figure 5d), and knockdown of ST8SIA1 significantly reduced the neuronal differentiation of mp AD-MSCs by more than 80% compared to the control (Figure 5e,f). The gene discussed is ST8SIA1; the disease is Alzheimer disease.