In peripheral tissues, the situation is different, and several studies have reported significant amounts of aggregates [14] of proteins such as SOD1 [15,16,17], C9orf72 [17,18,19], FUS [15,20], and TDP-43 [15,17,20,21] in ALS blood and tissues. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.