Evidence along these lines has been provided by studies demonstrating that KC play an important role in the FcγR-mediated clearance of circulating antigen–antibody conjugates or larger immune complexes (see, e.g., Reference [58]) or by intravital imaging studies showing that KC participate in the depletion of opsonized peripheral blood B cells in the liver [7]. The gene discussed is FCGR2A; the disease is keratoconus.