Of note, with respect to infection, the antibody-mediated triggering of FcγR may have contrasting effects: On the one hand, the opsonization of pathogens that normally evade degradation in lysosomes like Legionella pneumophila and Mycobacterium bovis bacillus Calmette–Guérin results in targeting them at lysosomes, where they are efficiently eliminated [30]. This evidence concerns the gene FCGR2A and infection.