Both US7 and TXL2 grew normally in vitro when co-cultured with both Gal3-KO and control OP9 cells over a two-week co-culture: viability (Figure S4A) and proliferation (Figure S4B) in the absence of stress were normal and, accordingly, no change was detected in the BCP-ALL cell cycle as determined by FACS-assisted measurement of DNA content (Figure S4C). This evidence concerns the gene LGALS3 and acute lymphoblastic leukemia.