We next determined the IC50 for Cpd17 in five different human ALLs including TXL2 (diagnosis, Ph-positive), US7 (diagnosis, no karyotype abnormalities), ICN06 (diagnosis, ETV6-Runx1), ICN3 (relapsed, MLL-AF4, infant ALL) and ICN13 (diagnosis, MLL-AF4, infant ALL). The gene discussed is KMT2A; the disease is acute lymphoblastic leukemia.