MAPT and Cognitive impairment: Indeed, adult rodents that underwent STZ infusion develop cerebral accumulation of Aβ [11], increased tau phosphorylation and aggregation [12,13], oxidative stress as revealed by increased levels of malondialdehyde and decreased levels of glutathione [14,15,16], changes in insulin signaling [17], dysmetabolism of glucose and energy production [18,19,20], down-regulation of ChAT activity [21], gliosis [12,22,23], caspase(s) activation and apoptosis [24], alteration in synaptic proteins and long-term cognitive deficits [20,25,26,27,28].