Dynamic studies performed using a focal segmental glomerulosclerosis rat model (adriamycin (ADR)-induced nephropathy) revealed a gradual increase in afamin and ceruloplasmin, as well as a gradual decrease in cadherin-2 and aggrecan core protein in FSGS, and suggested that decreased levels of fetuin-B, α-1-microglobulin, and α-2-HS-glycoprotein may be promising markers for the early detection of FSGS [96]. This evidence concerns the gene CP and focal segmental glomerulosclerosis.