CKD patients also demonstrated increased urinary excretion of plasma proteins and their fragments (e.g., A1AT, serum albumin, α-hemoglobin chain, and α-fibrinogen chain), kidney-specific proteins (uromodulin, gamma-chain Na+/K+-ATPase, and membrane-associated progesterone receptor component 1), and proteins excreted by the tubules, which may reflect chronic damage to the glomerular filtration barrier, increased glomerulosclerosis, and interstitial fibrosis. The gene discussed is UMOD; the disease is chronic kidney disease.