TTR and diabetes mellitus: A longitudinal study of type 2 DM revealed an increase in urine transthyretin/prealbumin and the Ig kappa C chain region within 0–5 years of the onset of DM; the appearance of cystatin C and ubiquitin after 5–10 years; and the detection of α-1-acid glycoprotein 1, apolipoprotein A1, AMBP, pigment epithelium-derived factor, and zinc α-2-glycoprotein after 10–20 years [74].