CD274 and central nervous system cancer: Lamano et al. identified Glioblastoma-Derived IL-6 as a cytokine that is necessary for inducing PD-L1 in Glioblastoma through a STAT3-dependent mechanism; they demonstrated that the inhibition of IL-6 signaling in orthotopic murine glioma models was associated with the decrease in PD-L1 expression and the reduction in of tumor growth and survival [34].