CD46 and cancer: Even though all of the studied and thus BBB crossing EV types expressed CD46 and ICAM-1, in general, the EV uptake rate could not be predicted by the presence of EV surface proteins such as CD46, AVβ6, AVβ3 and ICAM-1, nor by the species of the EV source, the cancer status or specific responses to LPS of WGA [65].