PCSK9 and familial hypercholesterolemia: Some “classical genes” used in previous targeted analyses, such as LDLR and LDLRAP1 for hypercholesterolemia, ANGPTL3 for hypocholesterolemia, and APOB and PCSK9 for both hypo- and hypercholesterolemia, have shown significant associations, while others, such as MTTP and SAR1B, have not.