Some “classical genes” used in previous targeted analyses, such as LDLR and LDLRAP1 for hypercholesterolemia, ANGPTL3 for hypocholesterolemia, and APOB and PCSK9 for both hypo- and hypercholesterolemia, have shown significant associations, while others, such as MTTP and SAR1B, have not. The gene discussed is PCSK9; the disease is Hypercholesterolemia.