NPPA and hematocrit: Clinically, PA manifests as HT resistant to antihypertensive therapy, often severe, accompanied by varied symptoms including muscle weakness, polyuria, increased thirst, paresthesia and muscle spasms, tetany (symptoms of severe potassium deficiency and alkalosis), normovolemia in the initial period and hypervolemia due to sodium and water retention followed by spontaneous diuresis and normalization of extracellular fluid volume (the “escape” phenomenon”), which is probably associated with increased secretion of atrial natriuretic peptide (ANP).