In a similar group of patients with end-stage renal disease, the risk of fatal and non-fatal cardiovascular events was significantly higher, after adjusting for confounders, in the highest vs. lowest tertile of soluble E-Selectin concentrations (HR 1.93, 95% CI 1.03 to 3.56) during a 21-month follow-up period [11]. The gene discussed is SELE; the disease is stage 5 chronic kidney disease.