Recently, more DUBs, such as ubiquitin-specific peptidase 9 X-linked (USP9X) [33], USP22 [34,35], and OTU domain ubiquitin aldehyde binding 1 (OTUB1) [36], were found to deubiquitinate and stabilize PD-L1 in different cancers. The gene discussed is CD274; the disease is cancer.