CD274 and cancer: Accordingly, inhibition of PD-L1 palmitoylation with a competitive inhibitor 2-BP and knock-out palmitoyltransferase ZDHHC9/DHHC3 decreases the cell surface membrane PD-L1 level and exhausts the storage of PD-L1 in endosomes, thereby enhancing immune clearance of cancer cells [55,56].