GSTM1 and neoplasm: Altogether, our findings demonstrate the capability of MSOT to provide multi-aspect imaging of tumor pathophysiology (e.g., oxygenation/hypoxia and apoptosis) based on simultaneous and co-registered imaging of both injected dyes (e.g., xPLORE-Apo-FL750©) and endogenous tissue chromophores (e.g., Hb/HbO2).