A study from Loi S et al. with TNBC demonstrated that MAPK activity can suppress the expression of MHC-I and MHC-II, intrinsically and those induced by interferon gamma (IFN-γ), which raises the hypothesis that the activation of MAPK via tumor cells can contribute to circumventing the antigen presentation pathways (Figure 3) [90]. The gene discussed is IFNG; the disease is neoplasm.