IL1B and Sepsis: In a mouse model of cecal ligation and puncture (CLP) sepsis, rGas6 treatment reduced lung serum levels of proinflammatory cytokines, such as IL-6 and IL-17, and mRNA levels of proinflammatory cytokines and chemokines, such as TNF-α, IL-1β, IL-6, IL-17, and MIP-2, at 20 h post-CLP [29].