Regenhardt et al. showed that intracerebroventricular (ICV) administration of Ang (1–7) in an ischemic stroke model blunted the increased levels of pro-inflammatory cytokines, e.g., interleukin (IL)-1α and IL-6, and chemokines e.g., CXCL12 and its receptor CXCR4, in addition to inhibiting microglia/macrophage activation within the cerebral cortex [22,25]. Here, ANGPT1 is linked to ischemic stroke.