In contrast to the deleterious actions of ACE-Ang II-AT1R, the angiotensin converting enzyme-2/angiotensin 1–7/Mas receptor (ACE2/Ang (1–7)/MasR) axis, a recently discovered arm of the renin angiotensin system (RAS), has been shown to beneficially influence outcomes in experimental stroke models and other cardiovascular diseases [23,24,25]. The gene discussed is ANGPT1; the disease is Stroke.