TNF and major depressive disorder: Mir-146a is a master regulator of ionized calcium binding adapter molecule 1 (Iba-1), a molecule upregulated in MDD associated with an increased level of inducible nitric oxide, IL-1β, TNF-α, interleukin 1 receptor associated kinase 1 (IRAK1), TNFα receptor-associated factor 6 (TRAF6) and phosphorylated NF-κB p65 [149].