The overexpression of miR-124 observed in patients with MDD also appears to modulate the function of several glutamatergic components, including Gria3 (glutamate receptor, ionotropic, Ampa3), Gria4 (glutamate receptor, ionotropic, Ampa4), Grin2a (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2A), Grin2b (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B) [81]. This evidence concerns the gene GRIN2A and major depressive disorder.