MiR-29 is essential for neuronal survival in the brain, targeting VDAC1MiR-29 is highly produced by astrocytes and their dysregulation in MDD may be an indicator of abnormal functioning of these cellsMiR-29b-3p is critical for inhibiting GRM4 expression in the prefrontal cortex of depressive-like rats MiR-29 is a major regulator of endoplasmic reticulum stress in neurons, a crucial pathophysiological event in the neurons related to MDD. This evidence concerns the gene GRM4 and major depressive disorder.