These targets included PI3K/Akt pathway (Let7b/c miR-26a-3p or miR-200) [85,133,134] whose dysregulation in MDD is related to a deficient neurotransmission, neuroprotection and neuroinflammation [135], MAPK (miR-15, miR-16, miR-24-3p, miR-146a/b and miR-425) [67,136], Wnt (miR-128-3p, miR-155 and MIR-221) [124,137,138] and other less recognized areas related to focal adhesion, TGF-β, ErbB or prolactin signaling pathways, pluripotency of stem cells, proteostasis, steroid biosynthesis, viral or bacterial infections, carcinogenesis and neurodegenerative diseases [132]. This evidence concerns the gene AKT1 and major depressive disorder.