IGF1R and stroke disorder: The variant rs28457673, affecting to miR-15/16/195/424/497 family appears to induce an aberrant signaling of insulin-like growth factor receptor 1 (IGF-1R) and MAP kinase (MAPK) pathway, which may be related with the appearance of post-stroke depression (PSD) [67], a poorly understood condition involving approximately one third of stroke survivors [68].