CREB1 and major depressive disorder: Hence, miR-124 alone is a parameter to consider but not a good predictive biomarker yet, although tendency in rodents is, that following a chronic unpredictable mild stress method, upregulating miR-124 worsens MDD behavior by targeting 3′ in cyclic AMP-responsive element-binding protein1 (CREB1) and BDNF in hippocampus, so it may be interesting to block it [123].