In men, the leptin/ghrelin ratio had a better capacity to identify patients with metabolic syndrome (AUROC = 0.923, Se = 76.9%, Sp = 100%) compared to leptin (AUROC = 0.821), ghrelin (AUROC = 0.718), or the HOMA index (AUROC = 0.654); p = 0.09 between the leptin/ghrelin ratio AUROC vs. AUROC-HOMA. Here, GHRL is linked to metabolic syndrome.