REN and cardiovascular disorder: Ghrelin, a stomach-derived hormone [30] secreted by P/D1 cells [17,63] also has an important role in short-term appetite regulation [11,17,30,64,65] and stimulation [11,26,27,60,63,66,67], but also involved in lipogenesis [67], insulin sensitivity, having anti-inflammatory properties [65], blocking the renin-angiotensin system [7,67], decreasing sympathetic activity [67,68], influencing blood pressure and heart rate [67,68], and finally being involved in cardiovascular disease development (low values being associated with increase global cardiovascular risk [54,69,70]).