DIRAS3 and ovarian carcinoma: A recent study suggests that treating DIRAS3-overexpressing ovarian dormant cancer cells with crizotinib further increases autophagy and induces apoptosis, and treating mice carrying DIRAS3-expressing ovarian cancer cells with crizotinib prolongs life span [148], even though, as mentioned above, DIRAS3-indcued autophagy supports dormant cancer cell survival.