LEF1 and Kaposi's sarcoma: Yao et al. demonstrated that vIRF1 and lymphoid enhancer binding factor 1 (Lef-1) binding induces circARGEF1 transcription, and circARGEF1 sponges miR-125a-3p to upregulate Glutaredoxin 3 (GLXR3) in vIRF1-transduced cells, KSHV-infected cells and KS tissues, promoting cell motility, proliferation and angiogenesis [256].